For the mechanical instrument, see Hemocytometer. Flow cytometry is routinely used in the diagnosis of health disorders, especially blood csc science, but has many other applications in basic research, clinical practice and clinical trials.
The first impedance-based flow cytometry device, using the Coulter principle, was disclosed in U. Patent 2,656,508, issued in 1953, to Wallace H. Mack Fulwyler was the inventor of the forerunner to today’s flow cytometers – particularly the cell sorter. For more historic details, see cytometry. Modern flow cytometers are able to analyze many thousand particles per second, in “real time,” and, if configured as cell sorters, can actively separate and isolate particles at similar rates having specified optical properties. A flow cytometer has five main components: a flow cell, a measuring system, a detector, an amplification system, and a computer for analysis of the signals.